Development of Novel Organic Reactions
Development of Efficient Synthetic Routes
Asymmetric Synthesis of Azasugars Using Chlorosulfonyl Isocyanate (CSI) Reaction
Development of Novel PTK6, HIF, and HDAC Inhibitors
Education
(B.S.) Seoul Nationl University, College of Pharmacy (1977)
(M.S.) Seoul Nationl University, College of Pharmacy (1977)
(Ph.D.) Department of Chemistry and Biochemistry, University of California, Los Angeles (1990)
Experience
Chairman, Korean Society of Organic Synthesis(2019)
Head, Gyeonggi Biocenter, GBSA (2016-2018)
President, Division of Organic Chemistry, The Pharmaceutical Society of Korea (2014)
Secretary General, The Pharmaceutical Society of Korea (2013-2104)
Visiting Professor, University of California, Los Angeles (2001-2002)
Associate and Full Professor, Sungkyunkwan University (1993-present)
Assistant Professor, Dongduk Womens University (1990-1993)
Post-doc., Harvard University (1989-1990)
Journal Articles
(2023)
Synthesis and biological evaluation of novel N-benzyltriazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY.
79,
1
(2023)
Synthesis and evaluation of ent-Conduramine C-1 derivatives as α-glucosidase inhibitors via CSI-mediated amination reaction.
CARBOHYDRATE RESEARCH.
524,
1
(2022)
Total synthesis of a-1-C-propyl-3,6-di-epi-nojirimycin and polyhydroxyindolizidine alkaloids via regio- and diastereoselective amination of anomeric acetals.
TETRAHEDRON.
116,
1
(2022)
Total Synthesis of Eliglustat via Diastereoselective Amination of Chiral para-Methoxycinnamyl Benzyl Ether.
MOLECULES.
27,
8
(2021)
Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3K8-specific inhibitors for the treatment of hematologic malignancies.
BIOORGANIC MEDICINAL CHEMISTRY.
45,
1
(2020)
Synthesis and biological evaluation of quinoxaline derivatives as specific c-Met kinase inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.
30,
13
(2020)
Total synthesis of chromanol 293B and cromakalim via stereoselective amination of chiral benzylic ethers.
TETRAHEDRON LETTERS.
61,
5
(2019)
Site-Selective C-H Alkylation of Diazine N-Oxides Enabled by Phosphonium Ylides.
ORGANIC LETTERS.
21,
16
(2019)
Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY.
27,
15
(2019)
Synthesis of (2H)-Indazoles from Azobenzenes Using Paraformaldehyde as a One-Carbon Synthon.
ADVANCED SYNTHESIS & CATALYSIS.
361,
7
(2018)
Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines.
ORGANIC LETTERS.
20,
13
(2017)
Rhodium(III)-Catalyzed Diastereoselective Synthesis of 1-Aminoindanes via C-H Activation.
ADVANCED SYNTHESIS & CATALYSIS.
359,
22
(2017)
Synthesis and Anticancer Evaluation of 2,3-Disubstituted Indoles Derived from Azobenzenes and Internal Olefins.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY.
42
(2017)
Total Synthesis and Anti-inflammatory Evaluation of Penchinone A and Its Structural Analogues.
JOURNAL OF ORGANIC CHEMISTRY.
82,
21
(2017)
Total synthesis of (-)-codonopsinine via regioselective and diastereoselective amination using chlorosulfonyl isocyanate.
TETRAHEDRON.
73,
30
(2017)
Synthesis and Cytotoxic Evaluation of N-Aroylureas through Rhodium(III)-Catalyzed C-H Functionalization of Indolines with Isocyanates.
ADVANCED SYNTHESIS & CATALYSIS.
359,
13
(2017)
Synthesis and anti-inflammatory evaluation of N-sulfonyl anthranilic acids via Ir(III)-catalyzed C-H amidation of benzoic acids.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.
27,
10
(2017)
Rhodium-Catalyzed [3+2] Annulation of Cyclic N-Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones.
JOURNAL OF ORGANIC CHEMISTRY.
82,
7
(2017)
Site-selective Cp* Rh(III)-catalyzed C-H amination of indolines with anthranils.
ORGANIC CHEMISTRY FRONTIERS.
4,
2
(2017)
Installation of alpha-ketocarboxylate groups to C7-position of indolines via C-H addition and oxidation approach under ruthenium catalysis.
TETRAHEDRON.
73,
13
신규한 HDAC6 억제제를 이용한 치매 또는 인지장애 예방 또는 치료용 약학적 조성물.
10-2018-0045283.
20200212.
KOREA, REPUBLIC OF
(S)-다포세틴 염산염의 제조방법.
10-2012-0010093.
20140328.
KOREA, REPUBLIC OF
(1R,2R,3R)-3-아미노사이클로펜탄-1,2-디올을 포함하는 항알러지용 조성물.
10-2011-0032771.
20130829.
KOREA, REPUBLIC OF
(1S,2S,3S,4S)-5-아미노사이클로펜탄-1,2,3,4-테트라올을 포함하는 항비만 조성물.
10-2010-0007547.
20111012.
KOREA, REPUBLIC OF
신규 벤조퓨란 유도체와 이를 포함하는 부정맥 예방 및 치료용 조성물.
10-0760676.
20070914.
KOREA, REPUBLIC OF
신규 벤조푸란 유도체를 포함하는 부정맥 예방용 식품.
10-0752613.
20070821.
KOREA, REPUBLIC OF
Pharmaceutical compositions comprising chelidonine or derivatives thereof.
CN 1254243 c.
20061117.
CHINA
아피쿨라렌 A의 제조방법.
10-0632696.
20060929.
KOREA, REPUBLIC OF
소라렌 또는 그 유도체를 포함하는 부정맥의 예방 및 치료용 조성물.
10-0627828.
20060918.
KOREA, REPUBLIC OF
항암활성이 있는 티몰 유도체 및 이를 포함하는 항암제.
10-0623095.
20060905.
KOREA, REPUBLIC OF
Pharmaceutical composition comprising chelidonine or derivatives thereof.
US 6,887,882 B2.
20050503.
UNITED STATES
Apicidin-derivatives, there synthetic method, and antitumor compositions containing the same..
US 6,831,061 B2.
20041214.
UNITED STATES
Thymol derivatives having anti-tumor activity, and anti-cancer agent comprising the same.
US6,255,517B1.
20010703.
UNITED STATES
Asiatic acid derivative, it's manufacturing method and dermatological
agent containing it..
GB 2 309 695.
19990301.
UNITED STATES
Conference Paper
(2019)
Regioselective and Stereoselective Amination with Use of Chlorosulfonyl Isocyanate and Its Application to Synthesis of N-Containing Bioactive Compounds.
International Symposium on Pharmaceutical Sciences in Sendai 2019.
JAPAN
(2019)
Asymmetric Total Synthesis of (-)-Bugecinine.
2019 Fall International Convention of the Pharmaceutical Society of Korea.
KOREA, REPUBLIC OF
(2019)
Synthesis of conduramine C1 derivatives as glucosidase inhibitors using chlorosulfonyl isocyanate.
2019 Fall International Convention of the Pharmaceutical Society of Korea.
KOREA, REPUBLIC OF
(2019)
Total synthesis of quinolizidine alkaloid using chlorosulfonyl isocyanate (CSI)-mediated amination reaction at anoeric acetal of sugars.
2019 Fall International Convention of the Pharmaceutical Society of Korea.
KOREA, REPUBLIC OF
(2019)
Synthesis and biological evaluation of thiazole hydroxamate derivatives as HDAC6 inhibitor.
20th Tetrahedron Symposium.
THAILAND
(2019)
Total Synthesis of (+)-DMDP and (+)-hyacinthacine A2.
2019 ACS National Meeting.
UNITED STATES
(2017)
Asymmetric Total synthesis of (+)DMDP and Hyacinthacine A2 using chlorosulfonyl isocyanate via a highly regioselective and diastereoselective allylic amination.
18th Tetrahedron Symposium.
HUNGARY
(2017)
Divergent total synthesis of D-ribo-phytosphingosine and L-ribophytosphingosine from D-ribose.
18th Tetrahedron Symposium.
HUNGARY
(2017)
Synthesis and Biological Evaluation of Hydroxamate Compounds as HDAC6 Inhibitors.
10th Joint Meeting on Medicinal Chemistry.
CROATIA
(2017)
Asymmetric Synthesis of (-)-Codonopsinine using Chlorosulfonyl Isocyanate via CSI-mediated Regio- and Stereoselective Amination.
제13회 대한약학회 약품화학분과학회 워크샵.
KOREA, REPUBLIC OF
(2017)
Synthesis, Molecular Docking and Biological Evaluation of Hydroxamates as HDAC6 Inhibitors.
제13회 대한약학회 약품화학분과학회 워크샵.
KOREA, REPUBLIC OF
(2017)
Asymmetric Synthesis of (-)-Codonopsinine using Chlorosulfonyl Isocyanate via a Regioselective and Stereoselective Amination.
2017 International Conventional of The Pharmaceutical Society Korea.
KOREA, REPUBLIC OF
(2017)
Design, Synthesis and Biological Evaluation of Hydroxamate Compounds as HDAC6 Inhibitors.
2017 International Conventional of The Pharmaceutical Society Korea.
KOREA, REPUBLIC OF
(2017)
Synthesis of Aminocyclopentitol Analogues via CSI-Mediated Stereoselective Amination.
2nd european organic chemistry congress.
NETHERLANDS
(2016)
Synthesis and Biological Evaluation of Hydroxamate Compounds as HDAC6 Inhibitors.
대한약학회 창립 70주년 국제학술대회.
KOREA, REPUBLIC OF
(2016)
Total Synthesis of Conduramine D-1 via C냐-Mediated a highly regioselective and diastereoselective allylic amination.
대한약학회 창립 70주년 국제학술대회.
KOREA, REPUBLIC OF
(2016)
Total Synthesis of Conduramine D-1.
17th Tetrahedron symposium.
SPAIN
(2016)
Total synthesis of DMDP and Hyacinthacine A2 via a Highly Regioselective and Diastereoselective Allylic Amination using Chlorosulfonyl Isocyanate.
17th Tetrahedron symposium.
SPAIN
(2016)
Total Synthesis of (+)-Hyacinthacine A2 and Its Derivatives via CSi-Mediated Stereoselective Amination.
International convention of The Pharmaceutical Society of Korea.
KOREA, REPUBLIC OF
(2016)
Total Synthesis of (+)-valienamine derivatives using chlorosulfonyl isocyanate via stereoselective amination.
International convention of The Pharmaceutical Society of Korea.
KOREA, REPUBLIC OF
